Havent had sex in 2 years....and my best friend is kind of gets around?

The last girl I had sex with was my girlfriend and its been 2 long years. I have had sex with 6 different girls but they all have been girlfriends so I've never really "hooked up". Im 24 years old, recently unemployed and had to move back home to my parents. Which doesnt exactly help. Im not exactly looking for a girlfriend, i just feel like after 2 years I just need to know what its like again. Its really depressing me and I dont want to end up being so desperate I take home a swamp creature. So recently I became really close friends with this one girl (I havent tried anything). She was there when I didnt really have anybody around and I never thought of her that way until recently. She has casual sex with a different person almost every month so I was wondering if one night we're kickin it if I should just make a move and explain to her the situation. Like shes on this whole "no relationships" kick and isnt really looking for anything either. A lot of the guys shes hooked up with are either terrible in the sac or get attached. I've known her for like 3 years but we didnt even really hang out or talk to each other until a couple months ago. I really dont wanna make it weird, but at the same time based off of how she is it shouldnt be weird to her if its not weird to me?